Researchers from Baylor College of Medicine in collaboration with Medterra CBD conducted the first scientific studies to assess the potential therapeutic effects of cannabidiol (CBD) on arthritis in dogs.
The researchers focused on these animals because the characteristics are very similar to the symptoms of arthritis in humans. Arthritis is the leading cause of pain and disability in the United States for which there is no effective treatment. Published in the journal PAIN, the study showed that CBD can significantly reduce the production of inflammatory molecules and immune cells associated with arthritis. As a result, the study showed that it improved the quality of life of dogs with arthritis, according to several reviews from owners and GPs.
"CBD is rapidly gaining popularity due to its anecdotal health benefits for a variety of conditions, from reducing anxiety to helping with movement disorders," said corresponding author Dr. Matthew Halper. "In 2019, Medterra CBD approached Baylor College to conduct independent scientific studies to determine the biological capabilities of several of its products."
Liposomes
In the current study, Halpert and his colleagues first measured the effect of CBD on immune responses associated with arthritis, both in human and murine cells grown in the laboratory and in mouse models. Using Medterra tinctures, they found that CBD treatment resulted in decreased production of both inflammatory molecules and immune cells related to arthritis. The researchers also found that the effect was faster and more effective when CBD was released encapsulated in liposomes than when it was administered 'naked'. Liposomes are artificially formed small spherical pouches used to deliver drugs and other substances into tissues with higher absorption rates.
Arthritis in dogs
Halpert and colleagues next assessed the effect of naked and liposome-encapsulated CBD on the quality of life of dogs with arthritis. “We studied dogs because experimental evidence shows that these animals are more suitable for assessing pain treatments in human arthritis than other animal models. The biological features of arthritis in dogs are very similar to the condition in humans. ” Arthritis is a very common condition in dogs. According to the American Kennel Club, it affects one in five dogs in the United States.
The 20 clients' dogs enrolled in the study were examined at Sunset Animal Hospital in Houston. The dog owners were randomly provided with identical medicine bottles containing CBD, liposomal CBD or a placebo. Neither the owners nor the vet knew what treatment each dog was receiving. After four weeks of daily treatment, owners and veterinarians reported on the dogs' condition. Whether they observed changes in the animals' pain level, such as positive changes related to running or walking. The dogs' blood and blood indicators of liver and kidney function were also assessed before and after the four weeks of treatment. "We have found encouraging results," said Halpert. “Nine out of ten dogs with CBD showed benefits, which lasted for two weeks after treatment was stopped. We did not detect any changes in the blood levels we measured, suggesting that the treatment appears to be safe under the conditions of our study. ”
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