Study: effect of cannabinoids versus melatonin

by Team Inc.


The Radicle Discovery Sleep Study is the first to compare the effect of cannabinoids with melatonin on sleep quality. Radicle Science and Open Book Extracts (OBX) stated that the majority of trial participants who received a cannabinoid product experienced significant improvement in sleep quality and duration.

The participants who received a cannabinoid product experienced less drowsiness than those who took melatonin. 1.800 participants were involved in the study. The Radicle Discovery Sleep Study was an Institutional Review Board (IRB) approved, blinded, randomized, controlled clinical trial evaluating the effects of various cannabinoid products relative to melatonin.

Cannabinoids for Sleep Studies

Five cannabinoid products, some of which contained additional rare cannabinoids, such as cannabinol (CBN) and cannabichromene (CBC) were compared with a control product containing only 5 mg of melatonin.
Radicle Science studied products supplied by OBX, an NSF and ISO 9001 certified manufacturer and distributor. Four of the five products showed a sleep improvement comparable to that of the melatonin control group.

OBX CEO Dave Neundorfer, commented: “This is fascinating data that is the first of its kind. This historical data reinforces our efforts to create the most effective formulations that improve well-being. “What's especially interesting is that cannabinoid formulations for sleep can also help people who experience anxiety and pain. Instead of having to take multiple products to address their ailments, they may just need to take one in the future.”

More and better sleep

The results showed that the onset of effects of all CBD products in the trial was similar to the melatonin control product, with most participants noticing an effect within an hour of ingestion. Throughout the study, the average amount of sleep gain experienced by participants from each product ranged from 34 to 76 extra minutes per night, but there was no statistically significant difference between the products.

More than 60 percent of participants in all studygroups experienced meaningful improvements in their sleep. A total of 71 percent of participants who took melatonin alone or melatonin in combination with CBD and CBN in a defined ratio saw significant improvement. Compared to 69 percent of participants who used a combination of CBD, CBN and CBC in a defined ratio.

The adverse reactions were mostly mild in nature, with no significant differences in the frequency of adverse reactions reported between all six study groups. However, the participants who received products containing cannabinoids, including the product containing cannabinoids and melatonin, reported a lower incidence of drowsiness than those who received melatonin alone.

In addition, the majority of participants who experienced an improvement in their pain and anxiety were those who took the combination of CBD, CBN, and CBC.

Potential of cannabinoids

The results suggest that the combination of certain cannabinoids and melatonin may provide a greater improvement in sleep duration than melatonin alone, and call for further research into these combinations, especially given animal studies suggesting an interaction between the endocannabinoid system and the pineal gland that produces melatonin.

Radicle Science CEO and co-founder Dr. Jeff Chen noted, “There are 50 to 70 million Americans with sleep problems. That is why scientifically validated research is more than necessary.” The next study from Radicle Science and OBX will be a blinded, randomized controlled trial of formulations containing the cannabinoid THCV to investigate its effects on energy, focus and appetite.

Source: (EN)

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