Masu bincike sun gano cewa CBD yana rage kumburi a cikin huhu na samfuran linzamin kwamfuta na COVID-19 ta hanyar haɓaka matakan peptide apeline.
Baya ga kowane irin gudu bincika game da yiwuwar yiwuwar magance COVID-19 tare da wiwi, maki sabon bincike An gano cewa cannabidiol (CBD) yana rage guguwar cytokine wanda ke lalata huhu kuma yana kashe marasa lafiya da yawa tare da COVID-19. Kungiyar ta ce CBD tana aiki ta hanyar ba da damar haɓaka matakan peptide na halitta da ake kira apeline, wanda ke rage kumburi.
An gudanar da binciken a Kwalejin Dental of Georgia (DCG) da Kwalejin Kiwon Lafiya na Georgia (MCG), duk a Amurka.
Masana kimiyya sun ce apelin peptide ne wanda kwayoyin halitta a cikin zuciya, huhu, kwakwalwa, adon nama da jini suke yi, kuma yana da mahimmin tsari wajen rage karfin jini da kumburi. Sun ce matakan jini na peptide sun kusa da sifili a cikin yanayin cututtukan numfashi (ARDS), amma ya ƙaru da 20 sau tare da CBD.
"Daidai, ARDS za ta haɓaka [peptide] a yankunan huhu inda ake buƙata don inganta jini da iskar oxygen don ramawa da kariya," in ji Dokta Babak Baban, mai kula da rigakafi na DCG.
Koyaya, lokacin da masu binciken suka kalli samfurin su na ARDS, Apelin bai yi ko ɗaya ba, a maimakon haka ya ragu a cikin huhun huhun kansa da kuma zagayawa gabaɗaya - har sai sun ƙara CBD.
Teamungiyar ta ba da rahoton wannan bazarar cewa maganin CBD ya rage ciwon huhu mai yawa, yana ba da damar haɓaka aikin huhu, ƙoshin lafiya oxygen, da kuma gyara wasu daga cikin lalacewar tsarin da huhun yake wanda yake na gargajiya a cikin ARDS.
Mai karɓa na ACE2
Kwayar COVID-19 tana shiga cikin kwayoyin halittar mutum ta hanyar kwayar halittar angiotensin mai canza enzyme 2, wanda aka fi sani da mai karɓar ACE2, tare da kamanceceniya da yawa tsakanin ACE2 da apeline, gami da gaskiyar cewa yawancin ƙwayoyin halitta da kyallen takarda suna da duka, gami da huhu.
Apelin da ACE2 galibi suna aiki tare don sarrafa karfin jini, kuma daidaitawa duka biyun na iya taimakawa cikin cututtukan zuciya, gami da gazawar zuciya, ta hanyar rage hawan jini yayin haɓaka ƙarfin zuciya na yin famfo.
Kwayar COVID-19 ta bayyana ta lalata wannan haɗin gwiwar, saboda kwayar cutar na da ikon ɗaurewa ga mai karɓar ACE2. An nuna wannan don rage matakan ACE2 da haɓaka matakan mahimmin bugun jini mai rikitarwa angiotensin II, saboda ƙarancin angiotensin II ya lalace kuma an samar da ƙananan vasodilatore (sinadarai da ke faɗaɗa jijiyoyin jini), yana ta daɗa hangen nesa na mai haƙuri.
Daga bincike: CBD a fili tana taka rawa
Yanzu masana kimiyya sun danganta waɗancan haɓakawa da tsarin apelin. Duk da yake ba sa sanya duk fa'idodin CBD ga peptide, a fili suna faɗin cewa yana taka muhimmiyar rawa. Sun kuma ce har yanzu ba su sani ba idan SARS-CoV-2 ko CBD suna da tasiri kai tsaye a kan apelin, ko kuma idan waɗannan sakamakon ƙasa ne, amma suna neman amsoshi.
“Kungiya ce; ba mu san abin da ke haifar da shi ba tukuna, amma alama ce mai kyau game da cutar, ”in ji Baban. Koyaya, ƙungiyar ta ce binciken da suka yi na rage ragi a cikin layin ARDS ya sa matakan peptide na kariya ya zama mai iya samar da kayan masarufi na farko don ARDS da amsa ga ƙoƙarin jiyya.
Teamungiyar ta gwada CBD a cikin ƙirar linzamin kwamfuta. Don waɗannan karatun, ƙungiyar kulawa ta karɓi maganin saline na intranasal na tsawon kwanaki uku a jere, yayin da samfurin COVID-19 ya sami samfurin analog na roba na RNA mai ruɓi biyu na intranasally kwana uku. Groupungiyar ta uku, ƙungiyar kulawa, sun karɓi RNA da CBD a cikin lokaci ɗaya.
Samfurori tare da ARDS sun rage matakan apelin sosai, yayin da suka haɓaka COVID-like bayyanar cututtuka idan aka kwatanta da sarrafawa. Jiyya tare da CBD na al'ada ba da amsa da matakan apelin, da matakan oxygen da kumburin huhu da tabo waɗanda ke halayyar ARDS.
Masu binciken sun ce matakai na gaba sun hada da kyakkyawar fahimtar hulda tsakanin CBD, Apelin da SARS-CoV-2, gami da dalilin da ya sa Apelin ke sauka ta fuskar kwayar cutar da dalilin da ya sa CBD ke kawo shi.
Bayanai sun hada da DrugTargetReview (EN(Eurekalert)EN), HealthEurope (EN), Labaran Duniya (EN)
