A cikin yaƙi da Covid-19, guguwar cytokine na ɗaya daga cikin mawuyacin abubuwan da likitoci ke yaƙi da su. Wannan alama a cikin mawuyacin hali na sabon kwayar cutar za ta iya haifar da yawan kumburi, kumburi, zafi da asarar kayan aiki. Hakanan yana iya haifar da tsarin garkuwar jiki sosai har ya kashe kwayoyin halittar jiki - maimakon yakar cutar kawai. A cikin mawuyacin yanayi, yana iya haifar da mutuwa, kamar yadda muka gani a yawancin lokuta na mai tsanani Covid-19.
A cikin 'yan watannin da suka gabata, masu bincike sun yi duba ko cannabis, tare da tarin ƙwayoyin cuta da yawa, na iya taimakawa wajen yaƙi da wannan mummunan tasirin ta hanyar rage kumburi. Kwanan nan muna da kyakkyawan sakamako gani daga binciken da ke nuna cewa CBD, wani fili a cikin cannabis, na iya taimakawa wajen yaƙar waɗannan guguwar cytokine.
Sakamakon farko na binciken da Isra'ila ke ci gaba da yi yanzu yana ƙara hoto na masu binciken da ke nuna cewa abubuwan da ke cikin tabar wiwi na iya zama babban jiyya a yaƙi da Covid-19. Amma wannan binciken ya ce terpenes, mahadi waɗanda ke ba da ƙamshi da ɗanɗano a cikin cannabis da sauran tsire-tsire masu yawa, na iya haifar da sakamako mafi kyau fiye da CBD kaɗai, mai yuwuwa fiye da jiyya na al'ada kamar corticosteroids.
Rahotanni daga binciken sun nuna cewa hadewar CBD tare da kayan lambu ya ninka tasiri sau uku a hana ayyukan cytokine fiye da dexamethasone, wanda shine corticosteroid wanda wani binciken da aka yi kwanan nan ya tabbatar da cewa magani ne mai inganci ga guguwar cytokine ta Covid-19.
Sabon binciken terpene din ana gudanar dashi ne daga wasu kamfanonin bincike da ci gaban Isra’ila guda biyu, Eybna, wanda ya kware a magungunan terpene, da kuma CannaSoul Analytics, wanda yake jagoranta Farfesa David "Dedi" Meiri, PhD, sanannen mai binciken cannabis ne kuma masanin ilimin halittu wanda ya yi nazarin cannabis don amfani dashi a cikin yanayi kamar cutar kansa da cutar Alzheimer. Wannan sabon binciken da aka kirkira don gano ko antipennor terpenes zai iya taimakawa rage hadarin cytokine mai hadari, kuma idan haka ne, ta yaya zasu kwatanta da sauran hanyoyin da ake samu.
Nazarin yana duban tsarin mallakar kayan abinci mai suna NT-VRL ™, wanda Eybna yayi don maganin yanayin kumburi irin su cututtukan guguwar cytokine da aka samo a cikin marasa lafiyar Covid-19. Irƙirar tana ƙunshe da ƙananan alamomin mutum 30 waɗanda ke da yiwuwar wakilai masu kashe kumburi kuma ana ɗaukarsu amintattu don amfani.
Masanin kimiyyar bayanai Nadav Eyal, wanda ya kirkiro shi kuma Shugaba ne na Eybna, ya bayyana cewa sun yi amfani da "hakar bayanan halittu, sarrafa bayanai da kuma tsara zane" don kirkirar "wani tsari wanda ya dace da takamaiman yanayin kiwon lafiya" kamar hadari na cytokine.
Ya ce wannan hanyar ci gaban "ta bude sabuwar duniya don samar da ingantaccen tsari na zamani - tare da karfin warkewa wanda mutum ke aiki da sinadaran magani masu wahalar hadawa."
A wasu kalmomin, kodayake yawancin magunguna suna ɗauke da sinadarin aiki guda ɗaya, wannan ƙirƙirar ta ƙunshi abubuwa daban-daban guda 30 waɗanda duk suke aiki tare don ƙirƙirar fa'idodi masu amfani.
Assasshen Guguwa ta Cytokine
Don gwada wannan samfurin terpene, masu bincike sunyi amfani da "Cytokine Storm Assay" daga Cannasoul, wanda Dr. Meiri ya ce yana da kyau sosai kuma yana ba da izini don "kimantawa na Cutar Saurin Cutar Cytokine". Amfani da ƙwayoyin jinin ɗan adam, gwajin yana taimaka wa masu bincike don tantance tasirin magunguna daban-daban kan ɓoyukan cytokine - babban abin da ke haifar da guguwar cytokine a cikin mawuyacin hali na Covid-19.
Tare da tsarin NT-VRL ™ terpene, masu bincike sun gwada CBD, CBD tare da NT-VRL ™ da Dexamethasone ta amfani da wannan gwajin. Dexamethasone an hada shi saboda shine corticosteroid da ake amfani dashi sau da yawa don rage kumburi. A wani binciken da aka yi kwanan nan a Burtaniya, an gano ya rage yawan mace-mace da kashi daya bisa uku a yayin karbar asibiti tare da Covid-19 ta amfani da iska. Da Kungiyar Lafiya ta Duniya a halin yanzu yana sabunta shawarwarinsa tare da amfani da dexamethasone ko wasu corticosteroids a cikin mawuyacin hali na Covid-19.
An gwada kowane mahadi don ganin yadda ya shafi aikin cytokine, kuma sakamakon yana da ɗan girgiza. Ba wai kawai ƙirƙirar ƙasa ta iya hana aikin cytokine ba (tare da kyakkyawan sakamako a manyan allurai), amma kuma ya wuce duka CBD da dexamethasone. CBD kadai ya hana game da 75% na cytokines a matsakaita, yayin da terpenes shi kaɗai ya hana game da 80%, yana ba da shawarar cewa haɗin Eybna na terpene na iya zama ma fi tasiri fiye da CBD don rage kumburi.
Duk da haka, mafi kyawun sakamako ya fito ne daga haɗin CBD da NT-VRL ™ terpene, wanda zai iya hana kusan 90% na cytokines da aka gwada. Idan aka kwatanta, dexamethasone zai iya hana kusan 30% na cytokines, yana mai cewa haɗakar CBD da terpenes sun ninka sau 2 fiye da magani na yanzu.
"Sakamakon farko ya kasance mai kyau," in ji Eyal, ya kara da cewa "suna nuna gagarumin aiki na maganin kumburi na terpenes kuma suna karya tunanin cewa terpenes kawai dandano ne da kamshi tare da tasirin maganin wuribo."
Duk da yake wannan nazarin a cikin vitro yana ba da muhimmiyar fahimta game da yiwuwar amfani da terpenes da CBD a cikin yaƙi da Covid-19, yana da mahimmanci a lura cewa waɗannan sakamakon sun fito ne daga binciken da ke gudana wanda har yanzu ba a kammala shi ba daga takwarorinsu. ana bita ko bugawa. Wadannan sakamakon har yanzu ba'a sake tantance su ba kuma sun inganta su ta hanyar mafi yawan al'umman kimiyya, amma idan sun tabbatar da cewa suna daidai, zasu iya haifar da gwajin mutum don bincika ko wannan haɗin na CBD da terpenes yana aiki da gaske ga marasa lafiya tare da Covid-19- cututtukan haɗari na cytokine
Sources ciki har da Forbes (EN), TheFreshToast(EN)
