A na-achọta CBD n'ọtụtụ ngwaahịa sitere na cannabis. Nke ahụ bụ n'ihi na ogige ahụ na-enye ọtụtụ uru ahụike.
Mbiri nke cannabidiol, CBD bụ otu n'ime ọtụtụ ogige ọgwụgwọ ewepụtara na cannabis. Osisi cannabis nwere ihe karịrị 100 kemịkalụ bara uru nke ọgwụ a maara dị ka cannabinoids. Agbanyeghị, CBD bụ otu n'ime cannabinoids abụọ kachasị ewu ewu na nke akwadoro. Nke ọzọ bụ tetrahydrocannabinol (THC).
Cannabidiol na tetrahydrocannabinol na-adịkarị iche dabere na mmetụta ha niile. THC bụ ogige wii wii kachasị ewu ewu na-ebute 'oke'. CBD, n'aka nke ọzọ, abụghị psychotropic na-adịghị egbu egbu. N'ihi nnukwu ọgwụgwọ ọgwụgwọ nke cannabidiol na enweghị mmetụta na-agbanwe uche, a na-edekarị ogige ahụ maka ọtụtụ ọnọdụ ahụike. Mgbu bụ otu n'ime nsogbu ndị a na-ahụkarị ị nwere ike iji CBD dozie. Ntugharị a na-eleba anya na isi ihe isii ị kwesịrị ịma mgbe ị na-eji CBD maka enyemaka mgbu.
CBD na-agwọ mgbu site na-emetụta usoro endocannabinoid gị
Ngwaahịa Cannabidiol, dị ka Ndị agha CBD na CBD tinctures, na-arụ ọrụ analgesic ha bụ isi site na-emetụta usoro endocannabinoid. Usoro endocannabinoid bụ usoro na-achịkwa mkpụrụ ndụ dị mgbagwoju anya mara maka ọrụ ya na njikwa mgbu. Usoro a na-etinyekwa aka n'ọtụtụ ọrụ ndị ọzọ, gụnyere ịnọgide na-enwe nguzozi endocrine dị mma yana ịhazi usoro n'ụra gị.
Ugbu a usoro endocannabinoid nwere usoro nke ndị na-anabata endocannabinoid. Ndị na-anabata endocannabinoid a na-ahụkarị gụnyere ndị na-anabata CB1 na ụbụrụ na sistemu ụjọ nke etiti yana ndị na-anabata CB2 na nsọtụ na akụkụ akụkụ ahụ. Usoro ahụ nwekwara ụfọdụ neurotransmitters a na-akpọ endocannabinoids na enzymes nke na-emetụta arụmọrụ zuru ezu.
Mgbe ejiri ya, ọ na-emetụta cannabidiol ndị na-anabata vanilloid, otu ndị na-anabata endocannabinoid na-akwalite nnyefe mgbu. CBD na-agwọkwa mgbu site n'ịbawanye akara anandami. Anandamide bụ neurotransmitter nke na-arụkwa ọrụ dị oke egwu na mgbasa ozi mgbu. CBD na-emezi akara anandami site na igbochi enzymes na-akụda neurotransmitter. Otu n'ime enzymes dị otú ahụ bụ fatty acid amide hydrolase (FAAH).
CBD nwere ike ịgwọ mgbu nociceptive
Ihe mgbu nociceptive na-ezo aka na mgbu nke mmerụ ahụ sitere na anụ ahụ, akwara, ma ọ bụ ọkpụkpụ. Ihe na-akpatakarị mgbu nociceptive gụnyere ihe mberede ụgbọ ala na mmega ahụ siri ike.
Ọtụtụ ụdị mgbu nociceptive dị oke. Nnukwu mgbu nwere ike ịdị oke egwu. Ọ dabara nke ọma, CBD nwere ike imekọrịta ihe na nociceptors nke anụ ahụ (ndị na-anabata ihe mgbu) n'ụzọ na-ebelata ihe mgbu nociceptive.
Mmalite nke Akwara ahụ mgbu (DOMS) bụ otu n'ime ọtụtụ ụdị mgbu nociceptive nke ị nwere ike ịgwọ na cannabidiol.
CBD nwekwara ike ịgwọ mgbu neuropathic
Ihe mgbu Neuropathic na-esite na nrụgide dị ukwuu na esemokwu na irighiri akwara. Ọrịa na-adịghị ala ala na-ebutekarị ụdị mgbu a. E gosipụtara Cannabidiol ka ọ dị irè megide ma nociceptive na neuropathic mgbu. Usoro na-ebelata ihe mgbu nke CBD bụ otu, n'agbanyeghị ụdị mgbu. Ngwakọta ahụ na-eme ka mmetụta mgbu na-emetụ n'ahụ site na ịmekọrịta ihe mgbu na-ebufe ndị na-anabata ya.
Mmetụta dị mma nke cannabidiol na mgbu neuropathic bụ ihe mere a na-ejikarị akwado ogige ahụ maka ọrịa dị iche iche na-adịghị ala ala nke na-akpata mgbu dị ka isi ihe mgbaàmà. Ihe atụ gụnyere ogbu na nkwonkwo, endometriosis, multiple sclerosis (MS), fibromyalgia, na ọrịa kansa. CBD nwekwara ihe mgbochi neuroprotective. Ngwakọta ahụ nwere ike si otú a gbochie mmebi ọzọ nke neurons nke ọnọdụ na-adịghị ala ala kpatara.
CBD nwere ike ịgwọ mbufụt
Na mgbakwunye na ịbụ nsonaazụ kpọmkwem nke nsogbu na nociceptors gị ma ọ bụ mmebi nke irighiri akwara na neurons gị, ọ pụkwara ịkpata mgbu ahụ na-apụtaghị ìhè site na mbufụt. Ọtụtụ nchọpụta egosila na cannabidiol nwere ihe mgbochi mkpali dị ike. CBD na-agwọ mbufụt site na igbochi ọrụ cytokines na chemokines, protein ndị bụ isi na-ebute mmeghachi omume mkpali nke ahụ.
Cannabidiol nwekwara Njirimara nke vasodilator† Dị ka vasodilator, CBD nwere ike inye aka gbasaa arịa ọbara dị warara. Nke a nwere ike belata ihe mgbu na-esite na mbelata na mbufụt nke akwara na veins. Ihe atụ nke mgbu nke mgbasa ọbara na-adịghị mma kpatara bụ isi ọwụwa na mgbu obi.
CBD nwere ike ịchịkwa ụfọdụ mmetụta mgbu
Nchegbu, nchekasị na ehighi ura bụ otu n'ime mmetụta ndị na-akpasu iwe. Ọ dabara nke ọma, ọnọdụ ndị a nwekwara ike ijikwa ihe mgbakwunye cannabidiol. CBD na-alụ ọgụ maka nchekasị na nchekasị site n'ịbawanye akara ngosi serotonin. Serotonin bụ neurotransmitter mara maka mmetụta 'mma' ya. Ọkwa serotonin dị elu nwere ike inye aka belata nchekasị nke mgbu na-akpata.
Cannabidiol nwekwara ike ịgwọ ọrịa ehighị ụra nke ọma, mmetụta ọzọ nke mgbu. Ngwakọta ahụ nwere ihe na-eme ka ahụ sie ike, nke nwere ike inye aka belata oge ụra. CBD na-agwọkwa ehighị ụra nke ọma site na belata oge ụra REM.
CBD anaghị ebuli gị elu
Nke a bụ nnukwu ihe kpatara ndị mmadụ ji eji cannabidiol megide tetrahydrocannabinol. CBD dị ọcha agaghị ebuli gị elu. Nke ahụ bụ n'ihi na ogige ahụ na-akpakọrịta na ndị na-anabata CB2 dị n'ihu ụbụrụ.
Ị nwere ike ịnye CBD maka enyemaka mgbu ma ọ bụ maka ọgwụgwọ ọgwụgwọ ndị ọzọ na-enweghị nchegbu maka ịtụtụrụ nkume. Enweghị mmetụta na-atụgharị uche na-enye gị ohere iji nlezianya nyochaa ọganihu gị.
Ihe ndị na-adịghị ahụkebe nke cannabidiol na-eme ka ọ dị mma maka ọgwụgwọ nke ọnọdụ mgbu na-emetụta akụkụ ndị dị n'akụkụ ụbụrụ, dị ka isi ọwụwa na maningitis.
Cannabidiol dị irè nke ukwuu megide mgbu. Ihe nwere ike inye aka jikwaa ma nociceptive na neuropathic mgbu. Mana dị ka ọ dị na ogige cannabis ọ bụla, CBD na-aba uru naanị mgbe ejiri ya mee ihe. Mfefe nke ngwaahịa anaghị arụpụta ihe.
Isi mmalite:
ncbi
ncbi
ncbi
frontiersin
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