IViki Likazwelonke Lokuqwashisa Ukuzala lihlose ukukhulisa ukuqonda kwenkinga yokungabi nenzalo nokwazi ukuthi izithandani ezi-1 kwezingu-6 ezithinteka yizo. I-cannabis iwathinta kanjani ama-hormone alawula isifiso sokudla, ingcindezi nokuzala?
Uma isifiso samabhanisi wekhofi noma amabhere we-gummy sasinganqandeki kuwe, kungenzeka ukuthi uhlangabezane namandla ama-hormone. Ngaphezu kokuvuselela izifiso zokudla okuthile, amahomoni amaningi omzimba nawo asiza ukukhulisa i-libido, ukulawula imizwa, ukulala, kanye nokushisa komzimba.
Abaningi bazibonela mathupha ukuthi insangu iba kanjani nemiphumela ecashile - noma cha ecashile emizwelweni yethu, ekulaleni nasekufiseni, ngakho-ke kuyacaca ukuthi lesi sitshalo sihlangana namahomoni ethu ngandlela thile. Kodwa kanjani?
Izinhlelo ze-endocannabinoid ne-endocrine
AmaHormone ayizithunywa zamakhemikhali eziwusizo ezifihliwe uhlelo lwe-endocrine, inethiwekhi yezindlala nezitho ezikhipha ama-hormone emzimbeni. Okubaluleke kakhulu izindlala ze-endocrine yi-hypothalamus, i-pituitary, i-pancreas, i-pineal gland, i-thyroid, i-parathyroid, i-adrenal, ama-ovari namasende.
"Kunama-hormone ahlukene angama-50 emzimbeni," kusho uDkt. Patricia Frye, MD, ongumqondisi omkhulu we Umphakathi Wabahlengikazi Bentsangu. "Amanye ama-hormone akhishwa ukukhuthaza izindlala ukuthi zikhiphe ama-hormone, kanti amanye ama-hormone asebenza ezithweni eziqondiwe ukuze alinganise imisebenzi ethile yokwenziwa komzimba."
Uhlelo lwe-endocannabinoid lungenye yamandla abalulekile wokulawula emzimbeni. Ukulala, imizwa, imetabolism, isifiso sokudla, ukukhula kwamathambo, ukuzala - uhlelo lwe-endocannabinoid ludlala indima kuzo zonke lezi zinqubo. Ososayensi bakholelwa ukuthi umsebenzi oyinhloko wohlelo lwe-endocannabinoid ukuletha le misebenzi ku-homeostasis noma ibhalansi.
"Ngokuvamile, insangu ihlangana nohlelo lwe-endocannabinoid, uhlelo lwe-neuromodulating olugcina ibhalansi noma i-homeostasis emzimbeni," kusho uFrye. Njengoba kunikezwe lokho, kunengqondo ukuthi uhlelo luqaphe cishe wonke ama-neurotransmitter nohlelo lwamahomoni. Sifunde ezinye zezindlela zalokhu kubhekwa, ikakhulukazi ezifundweni zezilwane ezandulelayo, kepha kusekuningi esingakuqondi kahle ukuthi lokhu kutholakala kuhumusha kanjani kubantu. "
Kodwa-ke, kunobunye ubufakazi bokuthi uhlelo lwe-endocannabinoid lubandakanyekile ekudleni, ekusebenzeni ngokocansi nasekucindezelekeni.
I-cannabis, ama-hormone endlala kanye ne-metabolism
Iningi lethu liyazazi izifiso ezisindayo ze-pizza eziza nokubhema ilunga. Insangu isivele yaziwa ukuthi ikhulisa isifiso sokudla futhi iqinise injabulo esiyitholayo ngenkathi sidla.
IGhrelin
Esifundweni esivela ku-2020, eshicilelwe ku-Nature, Abaphenyi bathole ukuthi amazinga e-ghrelin hormone ayephakeme ngemuva kokudla ngomlomo insangu esikhundleni sokubhema noma ukuvuthisa insangu. IGhrelin ibizwa ngothando njenge "hormone yokulamba" ngoba ivusa inkanuko futhi iguqule ukudla.
Iyanda ubufakazi futhi kuphakamisa ukuthi kunokusebenzisana ngokubambisana phakathi kohlelo lwe-endocannabinoid ne-ghrelin. Kokubili kukhulisa ukondleka, futhi ochwepheshe bakholelwa ukuthi laba bobabili basebenza ngokubambisana ukukhuthaza indlala nokudla. Ama-endocannabinoid nama-ghrelin receptors nawo ahlukaniswe ngokufanayo ezindaweni zobuchopho ezihlobene nokondleka nezitho ezithintekayo emzimbeni.
Leptin
Insangu nayo ithinta amazinga womzimba we-leptin womzimba. "ILeptin ifihlwa ngamangqamuzana anamafutha futhi ithumela amasiginali ku-hypothalamus ukulawula ukusetshenziswa kokudla namandla kagesi, okuvumela umuntu ukuthi agcine isisindo somzimba wakhe ojwayelekile noma iphuzu elibekiwe".
Ucwaningo lukhombisile ukuthi ababhemayo be-cannabis banamazinga aphansi e-leptin kunabangabhemi. Lokhu kutholakala kungachaza ukuthi kungani ababhemayo be-cannabis bevame ukuba namazinga aphansi amafutha omzimba nokukhuluphala.
"Uma unamafutha amaningi emzimbeni, i-leptin eyengeziwe isakazeka ukugcina lawo mafutha amaningi ngokwandisa isifiso sokwehlisa umzimba," kusho uFrye. "Abasebenzisi be-Cannabis futhi bane-BMI ephansi kanye nobubanzi bezinqe kunabo abangasebenzisi."
I-insulini noshukela
I-Cannabis nayo ibonakala ithinta amazinga e-insulin, i-hormone ebhekele ukulawulwa komzimba kwe-glucose. Lapho ukugxila okulungile kwe-insulin kuzungeza egazini, i-glucose iyiswa kumaseli ukuze isebenze njengophethiloli wokugcina amazinga wamandla.
Endabeni yabantu abanesifo sikashukela, amazinga e-insulin anele asho ukuthi i-glucose ayiqondiswanga kumaseli omzimba, kepha iyaqhubeka nokusakazeka egazini, ibangele i-hyperglycemia.
Ocwaningweni lwango-2020, ababambiqhaza abanikezwa i-placebo brownie babhekana nesipikha ekugxileni kwe-insulin egazini. Lokho kuhle ukubikezela - abaningi bethu bayazi inani eliphakeme, bese kuba ukungavikeleki okungenakugwemeka, okuza nokushaya ushukela.
Kodwa-ke, lapho ababambiqhaza benikezwa i-brownie efakwe i-THC, i-insulin spike yaba buthuntu. Kungakhathaliseki ukuthi i-cannabis yayidliwe ngomlomo, ibhenywa, noma ifakwe umoya, amazinga e-insulin ahlala ephansi kakhulu kunezilawuli.
Kuyaphawulwa futhi ukuthi i-CBD ihlotshaniswe nokuthuthukiswa kwe-glucose metabolism.
“Izilingo zabantu ziyashoda, kepha kokuhlangenwe nakho komtholampilo akuvamile ukubona iziguli ezinesifo sikashukela sohlobo olungu-2 ezikhuphuka ngemithamo yezidakamizwa ushukela ngemuva kokuqala i-CBD. Lokhu kungaba ukusebenza kwemiphumela elwa nokuvuvukala noma yokunciphisa ukucindezeleka kwe-CBD, noma umphumela oqondile ku-glucose metabolism kanye / noma ukuzwela kwe-insulin. ”
Ake sikhulume ngocansi, uju… nensangu
Kuthiwani ngethonya le-cannabis kwezinye izifiso? AmaHormone ayinto ebalulekile ekuqhutshweni kocansi nokuzala. Abasebenzisi be-cannabis abajwayelekile bavame ukuphikisana ngokuthi i-cannabis ivuselela noma icindezela i-sex drive.
Ama-receptors e-Cannabinoid atholakale kwabesilisa nabesifazane ama-hormone abesifazane nasezindlala ze-endocrine ezibandakanyeka ekuzaleni nasekuzaleni, kufaka phakathi i-hypothalamus, i-pituitary, ama-ovari namasende.
“Insangu ivuselela ukukhishwa kwe-oxytocin, eyaziwa nangokuthi yi-" hug hormone ". Inesibopho semisebenzi yokuzala njengokufinyela kwesibeletho ngesikhathi sokubeletha nokuncelisa, ”kuchaza uFrye. "I-Oxytocin nayo ibhekele ukwaneliseka okutholwa abantu ngokuxhumana nabantu futhi ithuthukisa ukusondelana ngokomzwelo."
Kunobufakazi obuphikisanayo ngemiphumela yensangu ekuzaleni kwabesilisa. "Ucwaningo lwango-2015 kubantu lukhombise ukwehla okungu-29% kwesibalo sesidoda, njengoba kwenze nezifundo eziningi ezandulela ukuqeqeshwa". "Kodwa-ke, ucwaningo lwango-2019 lwamadoda ahlolwe ukungabi nenzalo luthole ukuthi abesilisa abazibika ukuthi babhema njalo insangu banesibalo esiphezulu sesidoda kunabesilisa abangakaze babheme iwunga."
Ukusetshenziswa kwesikhashana kwe-cannabis kungakhulisa i-libido, kepha ukusetshenziswa okungapheli nakho kungadala ukungasebenzi kahle kwe-erectile. "Yize imithamo ephansi ukuya kokulinganisela ye-THC ingakhuthaza ukunamathela, inyuse ukuvusa futhi ivuselele ukwakhiwa, i-THC eningi kakhulu ingadala ukukhathazeka noma ivimbele ukuphuma kwe-ejaculation, okungathinta kabi ukuhlangana kocansi."
Uma kukhulunywa ngabesifazane, okutholakele kuyafana. Ngokusho kwe- ukubuyekeza kusuka ku-2019 insangu inganciphisa ukuzala kwabesifazane ngokuphazamisa i-hormone ekhipha i-gonadotropin, okuholele ekwehliseni ukukhiqizwa kwe-estrogen ne-progesterone. Abasebenzisi be-cannabis besifazane nabo bangathola ukuwohloka okuncike kumthamo ekusebenzeni kwe-ovarian kanye nokwehla kwe-hormone ebalulekile yokuzala i-estradiol.
"Angikukhuthazi ukusetshenziswa kwensangu kwabesifazane abazama ngamandla ukukhulelwa kanye / noma ukukhulelwa, ngaphandle uma inzuzo yokwelashwa kwe-cannabis idlula kakhulu ubungozi bokuzala okungasebenzi kahle."
Ngakolunye uhlangothi, insangu ibonakala ivusa idlingozi labesifazane lokuya ocansini. Ocwaningweni lwabesifazane ababike ukuthi basebenzisa insangu kwezocansi, u-68.5% uthe ulwazi lwabo oluphelele kwezocansi lujabulise kakhulu, u-60.6% ubike ukwanda kokushayela ucansi, kwathi abangu-52.8% bathi banokwanda kwama-orgasms anelisayo.
Misa Ukucindezelwa: Ukhula namazinga weCortisol
ICortisol iyi-hormone eyinhloko yokucindezela komzimba. Ngokushesha nje lapho i-cortisol ingena, imisebenzi engabalulekile yomzimba iyancipha, ivumela umzimba ukuthi ungene empini noma kumodi yendiza. Yize i-THC ku-cannabis ivame ukwandisa amazinga e-cortisol, okuhlangenwe nakho komuntu ngamunye kwemiphumela kuzohluka ngokuya ngemvamisa yokusetshenziswa.
Kwabanye abathengi, ukwanda kwe-cortisol kungakhuphula umfutho wegazi futhi kubangele ukukhathazeka. Abathengi besikhathi eside bangajwayela le spike ejwayelekile ye-cortisol, baphazamise impendulo ekucindezelekeni okukhulu.
Kodwa-ke, i-cortisol ayiyona kuphela isibopho sokuvuselela ukucindezeleka. Umthamo wasekuseni we-cortisol nawo ubalulekile ekuvukeni ekuseni - i-cortisol iphakama ekuseni futhi iyancipha kancane phakathi nosuku. Lesi sibalo sasekuseni senziwe buthuntu kubasebenzisi be-cannabis, okwenza kube inselele kakhulu ukususa ukozela nokungena osukwini.
I-Minder ijwayelekile
"Iseluleko esihle kakhulu engingasinikeza ukusebenzisa inani elincane lensangu elidingekayo ukuze kuzuzwe imiphumela oyifunayo," kusho uFrye. "Amazinga engeziwe ajikelezayo ama-cannabinoids angaholela emiphumeleni engadingeki."
Lokho kusho ukuthi i-cannabis ibonwe ukuthi ithuthukise izimpawu ezahlukahlukene ezihambisana nokungalingani kwe-endocannabinoid, okuholele ekuthuthukisweni kwempilo nokuphila kahle. "Lezi zinzuzo futhi zingaba umsebenzi wokulungiswa kwamahomoni obekungahle kulungiswe ngamazinga anele okusabalalisa ama-endocannabinoids."
Imithombo ifaka uMlimi (EN), Ngokucashile (ENTommys (EN)
